DES Third and Fourth Generations: Research Trends

Overview

Since 1990, there has been a significant range of published research articles that focus specifically on diverse effects of diethylstilbestrol (DES) in children born to mothers and fathers who were prenatally exposed to DES (i.e. third-generation “DES grandchildren”).

This section will continue to evolve as more research is identified, and a summary of key findings and trends in the literature will soon become available.

Frequently Listed Effects for Third Generation “DES Grandchildren”

(Under Development)

* Increased risk for neurodevelopmental effects, particularly ADHD
* Increased risk in DES granddaughters of irregular menses and amenorrhea
* Possible increase in infertility in DES granddaughters
* Increased risk of preterm delivery and possibility of ectopic pregnancy in DES granddaughters
* Increased risk of genital anomalies (particularly hypospadias) in DES grandsons

_______________________________________________

Journal References 1990-2023

2020-2023

• Birth Outcomes in DES Children and Grandchildren: A Multigenerational National Cohort Study on Informative Families (2023), by Laura Gaspari, et. al, published in the International Journal of Environmental Research and Public Health (full-text)
  
  
• Like Mother, Like Daughter, Like Granddaughter… Transgenerational Ignorance Engendered by a Defective Reproductive Health Technology (2022), by Emmanuelle Fillion & Didier Torny, published in the journal Reproductive Medicine & Society Online
  
  
• Exposure to Distilbène® in utero: Transgenerational Effects (2022), by Sylvie Epelboin, Michel Tournaire, & Emmanuel Devouche, published in the French journal Reproductive Medicine (Médecine de la Reproduction) (Abstract only)
  
  
• Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family (2021), by Marie-Odile Soyer-Gobillard, et. al, published in the International Journal of Environmental Research and Public Health (full-text)
  
  
• Are the Effects of DES Over? A Tragic Lesson from the Past (2021) by Pilar Zamora-Leon, published in the International Journal of Environmental Research and Public Health (full-text)
  
  
• Pregnancy Endocrine Disruption and Obesity-related Outcomes in the Third Generation (2021), by G. Yim, A. Roberts, and M. Weisskopf, produced by the journal Environmental Health Perspectives (Abstract only)
  
  
• Consequences of in utero Exposure to Synthetic Estrogens and Progestens for Children and Grandchildren (2021), by Marie Odile Soyer Goybillard, Laura Gaspari, and Charles Sultan, published in the International Journal of Clinical Studies & Medical Case Reports (full-text)
  
  
• Diethylstilbestrol Exposure During Pregnancy with Primary Clear Cell Carcinoma of the Cervix in an 8-year Old Granddaughter: A Multigenerational Effect of Endocrine Disruptors? (2021), by Laura Gaspari, et. al, published in the journal Human Reproduction
  
  
• The Heritable Legacy of Diethylstilbestrol: A Bellwether for Endocrine Disruption in Humans (2021), by Suzanne Robotti, published in the journal Biology of Reproduction
  
  
• Evidence of Intergenerational Transmission of Diethylstilbestrol Health Effects: Hindsight and Insight (2021), by Linda Titus, published in the journal Biology of Reproduction (abstract only)
  
  
• Consequences of in utero Exposure to Synthetic Estrogens and Progestogens for Children and Grandchildren (2021), by Marie Odile Soyer Gobillard, Laura Gaspari, & Charles Sultan, published in the International Journal of Clinical Studies & Medical Case Reports (full-text)
  
  
• Multigenerational Endometriosis: Consequence of Fetal Exposure to Diethylstilbestrol? (2021) by Laura Gaspari, et. al, published in the journal Environmental Health (full-text)
  
  
• “Idiopathic” Partial Androgen Insensitivity Syndrome in 11 Grandsons of Women Treated by Diethylstilbestrol During Gestation: A Multigenerational Impact of Endocrine Disruptor Contamination? (2020), by L. Gaspari, et. al, published in the Journal of Endocrinological Investigation (abstract only)
  
  
• Genital Tract and Reproductive Characteristics in Daughters of Women and Men Prenatally Exposed to Diethylstilbestrol (DES) (2020), by Anne Wautier, et. al, published in the French journal Therapies (Abstract only)
  
  
• Pregnancy Endocrine Disruption and Obesity-Related Outcomes in the Third Generation (2020), by G. Yim, A. Roberts, & M. Weisskopf, published in the journal Environmental Health Perspectives (Abstract only)
  
  
• Methodological Issues in Population-Based Studies of Multigenerational Associations (2020), by Glenn McGee, et. al, published in the American Journal of Epidemiology (full-text)
  
  
  2015-2019
  
  
• Reproductive and Hormone-Related Outcomes in Women whose Mothers were Exposed in utero to Diethylstilbestrol (DES): A Report from the U.S. National Cancer Institute DES Third Generation Study (2019), by Linda Titus, et. al, published in the journal Reproductive Toxicology (full-text)
  
  
• The Epigenetic Impacts of Endocrine Disruptors on Female Reproduction Across Generations (2019), by Saniya Rattan & Jodi A. Flaws, published in the journal Biology of Reproduction (full-text)
  
  
• Prenatal Diethylstilbestrol Exposure and Cancer Risk in Women (2019), by Rebecca Troisi, et. al, published in the journal Environmental and Molecular Mutagenesis (abstract)
  
  
• Pregnancy Drugs, Fetal Germline Epigenome, & Risks for Next-Generation Pathology: A Call to Action (2019), published in the journal Environmental and Molecular Mutagenesis
  
  
• Association of Exposure to Diethylstilbestrol During Pregnancy with Multigenerational Neurodevelopmental Deficits (2018), by Marianthi-Anna Kioumourtzoglou, et. al, published in JAMA Pediatrics (full-text)
  
  
• Diethylstilbestrol Exposure in Pregnancy Linked to Multigenerational Neurodevelopmental Deficits (2018), by Karen Rosenberg, published in the American Journal of Nursing (Abstract only)
  
  
• Birth Defects in Children of Men Exposed in utero to Diethylstilbestrol (DES) (2018), by Michael Tournaire, et. al, published in the French journal Therapies (full-text)
  
  
• Grandmaternal Diethylstilbestrol and Attention-Deficit/Hyperactivity in Children –Reply (2018), by Marianthi-Anna Kioumourtzoglou & Marc G. Weisskopf, published in JAMA Pediatrics (abstract only)
  
  
• Current Perspective of Diethylstilbestrol (DES) Exposure in Mothers and Offspring (2017), by Taher Al Jishi & Consolato Sergi, published in the journal Reproductive Toxicology (full-text)
  
  
• Adverse Health Effects in Children of Women Exposed in utero to Diethylstilbestrol (DES) (2016), by Michael Tournaire, et. al, published in the French journal Therapies (full-text)
  
  
• Diethylstilbestrol (DES): Also Harms the Third Generation (2016), published in the French journal Prescrire International (abstract only)
  
  
• DES Exposure and Third Generation Attention Deficit/Hyperactivity Disorder (2016), by Marianthi-Anna Kioumourtzoglou, et. al, published in the journal Environmental Health Perspectives (full-text)
  
  
• The History of Diethylstilbestrol told to Grandchildren–the Transgenerational Effect (2015), by Patrick Fénichel, Françoise Brucker-Davis, & Nicolas Chevalier, published in the journal Annales d’Endocrinologie (abstract only)
  
  
  1990-2011
  
  
• Transgenerational Neuroendocrine Disruption of Reproduction (2011), by Deena M. Walker and Andrea C. Gore, published in the journal Nature Reviews Endocrinology (full-text)
  
  
• Prevalence of Hypospadias in Grandsons of Women Exposed to Diethylstilbestrol during Pregnancy: A Multigenerational National Cohort Study (2011), by Nicolas Kalfa, et. al, published in the journal Fertility and Sterility (abstract only)
  
  
• Birth Defects in the Sons and Daughters of Women who were Exposed in utero to Diethylstilbestrol (DES) (2010), by Linda Titus-Ernstoff, et. al, published in the International Journal of Andrology (full-text)
  
  
• Offspring of Women Exposed in utero to Diethylstilbestrol (DES): A Preliminary Report of Benign and Malignant Pathology in the Third Generation (2008), by Linda Titus-Ernstoff, et. al, published in the journal Epidemiology (abstract only)
  
  
• Esophageal Atresia and Tracheoesophageal Fistula in Children of Women Exposed to Diethylstilbestrol in utero (2007), published in the American Journal of Obstetrics and Gynecology (abstract only)
  
  
• Adverse Effects of the Model Environmental Estrogen Diethylstilbestrol are Transmitted to Subsequent Generations (2006), by Retha R. Newbold, Elizabeth Padilla-Banks, & Wendy N. Jefferson, published in the journal Endocrinology (full-text)
  
  
• Hypospadias: A Transgenerational Effect of Diethylstilbestrol? (2006), by M. M. Brouwers, et. al, published in the journal Human Reproduction (full-text)
  
  
• Menstrual and Reproductive Characteristics of Women whose Mothers were Exposed in utero to Diethylstilbestrol (DES) (2006), by Linda Titus-Ernstoff, et. al, published in the International Journal of Epidemiology (full-text)
  
  
• Pregnant “DES Daughters” and their Offspring (2005), by Tal Schechter, Yaron Finkelstein, and Gideon Koren, published in Canadian Family Physician (full-text)
  
  
• Limb Reduction Deficits in the First Generation and Deafness in the Second Generation of Intrauterine-exposed Fetuses to Diethylstilbestrol (2003), by C. Stoll, Y. Alembik, & B. Dott, published in the journal Annales de Génétique
  
  
• Hypospadias in Sons of Women Exposed to Diethylstilbestrol in utero: A Cohort Study (2002), by H. Klip, et. al, published in the journal Lancet (full-text)
  
  
• Findings in Female Offspring of Women Exposed in utero to Diethylstilbestrol (2002), by Raymond H Kaufman & Ervin Adam, published in the journal Obstetrics & Gynecology
  
  
• Diethylstilbestrol, Teratogenesis, and Carcinogenesis: Medical/legal Implications of its Long-term Sequelae, including Third Generation Effects (1990), by Henry T. Lynch, et. al, published in the International Journal of Risk and Safety in Medicine (abstract only)
  
  
  >> Return to grad-mentor.com/des-diethylstilbestrol-research