Diethylstilbestrol (DES): Breast Cancer Research Trends 1979-2023

Below is a guide to published research with inclusion of overall trends in breast cancer risk and prevalence along with trends for women prenatally exposed to DES. DES references are excerpted from the master index of DES Multigenerational Research Trends, 1939 to 2023

>>> Historically, research on DES-exposed mothers as well as their daughters and granddaughters has identified an increased risk of developing breast cancer (cite Hilakivi-Clarke, 2014).

May 2023 Research Update

2020-2023

•  A Model for Predicting both Breast Cancer Risk and non-breast Cancer Death Among Women >55 Years Old (2023), by Mara A. Schonberg, et. al, published in the journal Breast Cancer Risk (full-text)
  
  
• Obesity and Breast Cancer: Interaction or Interference with the Response to Therapy? (2023), by Silvia Riondino, et. al, published in the journal Current Oncology (full-text)
  
  
• Etiology of Breast Cancer (2023), by Rajveer Singh & Nitesh Kumar Sain, published in the Journal of Pharmaceutical Negative Results (abstract)
  
  
• Parental Occupational Exposure to Chemicals and Risk of Breast Cancer in Female Offspring (2023), by Julie Elbaek Pedersen & Johnni Hansen, published in the journal Environmental Research (full-text)
  
  
• Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer (2023), by Ian H. Kunkler, et. al, published in the New England Journal of Medicine (abstract only)
  
  
• Identification and Strategies for Triple-negative Breast Cancer Subtypes (2023), by Rokhim Suryadi, et. al, published in the journal Science Midwifery (full-text)
  
  
• The Causal Effect of Reproductive Factors on Breast Cancer: A Two-Sample Mendelian Randomization Study (2023), by Lijun Jia, et. al, published in Journal of Clinical Medicine
  
  
• Trends in Breast Cancer Mortality by Race/Ethnicity, Age, and U.S. Census Region, United States, 1999-2020 (2023), by Taylor D. Ellington, et. al, published in the journal Cancer (abstract only)
  
  
• Cancer Statistics, 2023 (2023), by Rebecca L. Siegel, et. al, published in the journal CA: A Cancer Journal for Clinicians (full-text)
  
  
• Racial Disparities in Breast Cancer Treatment Patterns and Treatment-Related Adverse Events (2023), by Nickolas Stabellini, et. al, published in the journal Scientific Reports
  
  
• Internet-delivered Cognitive Behavioural Therapy for Depression and Anxiety in Breast Cancer Survivors: Results from a Randomized Controlled Trial (2023), by Selin Akkol-Solakoglu & David Hevey, published in the journal Psycho-Oncology (full-text)
  
  
• Emergency Department Visits and Hospitalizations in Older Women Treated for Early Stage Breast Cancer (2023), by Dillon C. Cockrell, et. al, published in the Journal of Geriatric Oncology (abstract only)
  
  
• Triple Negative Breast Cancer: Pitfalls and Progress (2022), by Paola Zagami & Lisa Anne Carey, published in the journal npj Breast Cancer (full-text)
  
  
• Breast Cancer Research, Current Therapeutic Pipeline Provide Significant Advancements in Diagnosis, Treatment (2022), by Rachel K. Anderson, published in Pharmacy Times Oncology Edition (full-text)
  
  
• Breast Cancer Statistics, 2022 (2022), by Angela N. Giaquinto, et. al, published in CA: A Cancer Journal for Clinicians (full-text)
  
  
• Current and Future Burden of Breast Cancer: Global Statistics for 2020 and 2040 (2022), by Melina Arnold, et. al, published in the journal The Breast (full-text)
  
  
• Understanding Breast Cancer as a Global Health Concern (2022), by Louise Wilkinson & Toral Gathani, published in The British Journal of Radiology (full-text)
  
  
• Endocrine Disrupting Chemicals and Breast Cancer: A Systematic Review of Epidemiological Studies (2022), by Murphy Lam Yim Wan, et. al, published in the journal Critical Reviews in Food Science and Nutrition (full-text)
  
  
• Diethylstilbestrol (DES) Exposure and Cancer (2021), published summary from the National Cancer Institute (full-text with links)–see section on Breast Cancer for comparative focus on level of risk
  
  
• Are the Effects of DES Over? A Tragic Lesson from the Past (2021), by Pilar Zamora-Leon, published in the International Journal of Environmental Research and Public Health (f-t)
  
  
• Evidence of Intergenerational Transmission of Diethylstilbestrol Health Effects: Hindsight and Insight (2021), by Linda Titus, published in the journal Biology of Reproduction (full-text)
  
  
• Breast Cancer–Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies–An Updated Review (2021), by Sergiusz Lukasiewicz, et. al, published in the journal Cancers (full-text) (overall study; not limited to DES)
  
  
• Cancer Progress and Priorities: Breast Cancer (2021), by Serena C. Houghton & Susan E. Hankinson, published in the journal Cancer Epidemiology, Biomarkers & Prevention (f-t)
  
  
• The Hypothesis of Fetal Origin of Breast Cancer: An Update (2021), by Tongzhang Zheng, et. al, published in the journal Women’s Health Research (full-text)
  
  
• Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer (2020), by Louisane Eve, et. al, published in the International Journal of Molecular Sciences (full-text)
  
  
• Breast Cancer in Women: A Descriptive Analysis of the National Cancer Database (2020), by Andrea Sisti, et. al, published in the journal Acta Biomedica (full-text)
  
  
• Prevalence and Intensity of Persistent Post-Surgical Pain Following Breast Cancer Surgery: A Systematic Review and meta-analysis of Observational Studies (2020), by Li Wang, et. al, published in the British Journal of Anaesthesia (abstract only)
  
  
  2010-2019
  
  
• Systematic Treatment and Radiotherapy, Breast Cancer Subtypes, and Survival after Long-term Clinical Follow-up (2019), by Sherry X. Yang & Eric C. Polley, published in the journal Breast Cancer Research and Treatment (full-text)
  
  
• Prenatal Diethylstilbestrol Exposure and Cancer Risk in Women (2019), by Rebecca Troisi, et. al, published in the journal Environmental and Molecular Mutagenesis (abstract only) 
  
  
• Prenatal Diethylstilbestrol Exposure and Mammographic Density (2018), by William C. Strohsnitter, et. al, published in the International Journal of Cancer (full-text)
  
  
• State of the Evidence 2017: An Update on the Connection Between Breast Cancer and the Environment (2017), by Janet M Gray, et. al, published in the journal Environmental Health (full-text)
  
  
• Cancer Risk in Women Exposed to Diethylstilbestrol in Utero (2015), by Michel Tournaire, et. al, published in the journal Therapie (abstract only)
  
  
•  Maternal Exposure to Diethylstilbestrol during Pregnancy and Increased Breast Cancer Risk in Daughters (2014), by Leena Hilakivi-Clarke, published in the journal Breast Cancer Research (full-text)
  
  
• Exposures to Synthetic Estrogens at Different Times During the Life, and Their Effect on Breast Cancer Risk (2013), by Leena Hilakivie-Clarke, et. al, published in the Journal of Mammary Gland Biology and Neoplasia (abstract only)
  
  
• Breast Cancer Following Diethylstilbestrol Exposure in Utero: Insights from a Tragedy (2012), by Hans-Olov Adami, et. al, published in the European Journal of Epidemiology (abstract only)
  
  
• Prenatal Exposure to Diethylstilbestrol and Long-term Impact on Breast and Reproductive Tract in Humans and Mice (2012), by R.R. Newbold, published in the Journal of Developmental Origins of Health and Disease (abstract only)
  
  
• Mammography Screening Behaviors of Women Exposed Prenatally to Diethylstilbestrol (2012), by Elizabeth A. Camp, et. al, published in the Journal of Women’s Health (abstract only)
  
  
• Adverse Health Outcomes in Women Exposed in utero t 0 Diethylstilbestrol (2011), by Robert N. Hoover, et. al, published in the New England Journal of Medicine (full-text)
  

• Cancer Risk in DES Daughters (2010), by Janneke Verloop, et. al, published in the journal Cancer Causes & Control (full-text)
  
  
  2000-2009
  
  
• Breast Cancer Screening in Women Exposed in utero to Diethylstilbestrol (2009), by Elizabeth A. Camp, et. al, published in the Journal of Women’s Health (full-text)
  
  
• Intrauterine Environments and Breast Cancer Risk: Meta-analysis and Systematic Review (2007), by Sue Kyung Park, et. al, published in the journal Breast Cancer Research (full-text)
  
  
• Cancer Risk in Women Prenatally Exposed to Diethylstilbestrol (2007), by Rebecca Troisi, et. al, published in the International Journal of Cancer (full-text)
  
  
• Intrauterine Factors and Risk of Breast Cancer: A Systematic Review and Meta-Analysis of Current Evidence (2007), by Dr. Fei Xue & Prof Karin B. Michels, published in the journal The Lancet: Oncology (abstract only)
  
  
• Diethylstilbestrol Increases Risk of Breast Cancer Death (2006), by Roger Dobson, published in BMJ (British Medical Journal) (news source)
  
  
• Prenatal Diethylstilbestrol Exposure and Risk of Breast Cancer (2006), by JuliR. Palmer, et. al, published in the journal Cancer Epidemiology Biomarkers & Prevention (full-text)
  
  
• Intrauterine Exposures, Pregnancy Estrogens and Breast Cancer Risk: Where do we Currently Stand? (2006), by Pagona Lagiou, published in the journal Breast Cancer Research (full-text)
  
  
• Management of Breast Cancer in Patients Prenatally Exposed to Diethylstilbestrol: Are we Prepared? (2005), by MS Mano, et. al, published in the journal The Breast (abstract only)
  
  
• Risk of Breast Cancer in Women Exposed to Diethylstilbestrol in utero: Preliminary Results (United States) (2002), by Julie R. Palmer, et. al, published in the journal Cancer Causes & Control (abstract only)
  
  
• Long-term Cancer Risk in Women Given Diethylstilbestrol (DES) during Pregnancy (2001), by L. Titus-Ernstoff, et. al, published in the British Journal of Cancer (abstract only)
  
  
  1979-2000
  
  
• Cancer Risk in Women Exposed to Diethylstilbestrol in Utero (1998), by Elizabeth E. Hatch, et. al, published in the Journal of the American Medical Association (JAMA) (abstract only)
  
  
• Diethylstilbestrol and Risk of Fatal Breast Cancer in a Prospective Cohort of U.S. Women (1996), by Eugenia E. Calle, et. al, published in the American Journal of Epidemiology (full)
  
  
• Diethylstilbestrol (DES) and Breast Cancer (1993), by KE Malone, published in the journal Epidemiological Review (abstract only)
  
  
• Breast Cancer in Mothers Prescribed Diethylstilbestrol in Pregnancy: Further Follow-up (1993), by Theodore Colton, et. al, published in the Journal of the American Medical Association (JAMA) (abstract only)
  
  
• Breast Cancer in Mothers Given Diethylstilbestrol in Pregnancy (1984), by E. R. Greenberg, et. al, published in the New England Journal of Medicine (abstract only)
  
  
• Diethylstilbestrol and the Risk of Cancer (1979), by L C Clark & K M Portier, published in the New England Journal of Medicine (abstract only)
  

>>> Return to grad-mentor.com/des-research