DES (Diethylstilbestrol) and Endocrine Disruptors: Research on Psychological, Psychiatric and Neurological Effects 1959-2025

August 2025 Comprehensive Update

Scott Kerlin, Ph.D., M.S.
DES International Information & Research Network
DES Research Overview: grad-mentor.com/des-research

Overview

Since the late 1970s, a growing amount of investigative and epidemiological research has been published in the United States and Europe which focuses on psychiatric, neurobehavioral and neurological, and psychological* issues among DES-exposed individuals. Research into the psychiatric effects of exposure to a variety of endocrine-disrupting chemicals (EDCs) has frequently included DES in its overview. This area of investigation continues to evolve as more research on multi-generational effects of DES exposure is documented, and additional relevant studies will be included in the future.

My full directory of DES and EDCs Multigenerational Research Publications 1939-2025 is available here.


Related Documented Effects in Published Literature on DES Daughters, Sons, and in DES Grandchildren:

Anxiety
— Attention Deficit Hyperactivity Disorder (ADHD)
— Autism Spectrum Disorders (ASD)
— Bipolar Disorders
— Depression, Mild and Severe
— Eating Disorders

Epigenetic Effects
— Learning Disabilities
— Mood and Behavioral Disorders

Neurological/Neurodevelopmental Disorders
— Psychosis

Schizophrenia risk
— Sexuality Effects and Gender Identity Effects(Dysphoria) *
— Somatic Disorders
— Suicidality


* Additional references with my specific detailed focus on DES and Sexuality, Gender Identity and Sexual Orientation, begun in the 1990s are also available. My comprehensive resource guide to research on human sexuality and gender identity is available separately.


2020-2025 Publications