DES: Psychological, Psychiatric and Neurological Effects

Overview

Since the late 1970s, a significant amount of investigative and epidemiological research has been published which focuses on psychiatric, neurobehavioral and neurological, and psychological issues among DES-exposed individuals. This area of research continues to evolve, and additional studies will be included in this directory as they are located.

Key topics included in this research will be summarized in times ahead.

The full directory of DES Multigenerational Research Trends 1939-2023 is available here.
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Journal References 1977-2023

1991-2023

• Diethylstilbestrol and Autism (2022), by M O Soyer-Gobillard, et. al, published in the journal Frontiers in Endocrinology (full-text)
  
  
• Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family (2021), by Marie-Odile Soyer-Gobillard, et. al, published in the International Journal of Environmental Research and Public Health (full-text)
  
  
• All in the Family: What Multigenerational Cohorts are Revealing about Potential Environmental Impacts on Neurodevelopment (2019), by Lindsey Konkel, published in the journal Environmental Health Perspectives (full-text)
  
  
• Association of Exposure to Diethylstilbestrol During Pregnancy with Multigenerational Neurodevelopmental Deficits (2018), by Marianthi-Anna Kioumourtzoglou, et. al, published in JAMA Pediatrics (full-text)
  
  
• Grandmaternal Diethylstilbestrol and Attention-Deficit/Hyperactivity in Children –Reply (2018), by Marianthi-Anna Kioumourtzoglou & Marc G. Weisskopf, published in JAMA Pediatrics (abstract only)
  
  
• Evidence for Link between Mental Disorders and in utero Exposure to Synthetic Hormones: A Long and Crucial History (2018), by M O Soyer-Gobillard, et. al, published in the open text Mental Disorders (same authors)
  
  
• Methylomic Changes in Individuals with Psychosis, Prenatally Exposed to Endocrine Disrupting Compounds: Lessons from Diethylstilbestrol (2017), by Fabrice Rivollier, et. al, published in the journal PLoS One (full-text)
  
  
• DES Exposure and Third Generation Attention Deficit/Hyperactivity Disorder (2016), by Marianthi-Anna Kioumourtzoglou, et. al, published in the journal Environmental Health Perspectives (full-text)
  
  
• Effects of Diethylstilbestrol Exposure During Gestation on both Maternal and Offspring Behavior (2015), by Kazuya Tomihara, et. al, published in the journal Frontiers in Neuroscience (full-text)
  
  
• Association Between Fetal DES-exposure and Psychiatric Disorders in Adolescence/adulthood: Evidence from a French Cohort of 1002 Prenatally Exposed Children (2015), published in the journal Gynecological Endocrinology (full-text)
  
  
• Diethylstilbestrol and Risk of Psychiatric Disorders: A Critical Review and New Insights (2012), by O Kebir & MO Krebs, published in The World Journal of Biological Psychiatry
  
  
• Association of Increased Prenatal Estrogen with Risk Factors for Schizophrenia (2010), by James S. Brown, published in the journal Schizophrenia Bulletin (full-text)
  
  
• Serious Psychiatric Outcome of Subjects Prenatally Exposed to Diethylstilboestrol in the E3N Cohort Study (2007), by Helene Verdoux, et. al, published in the journal Psychological Medicine (full-text)
  
  
• Physical and Psychological Problems Associated with Exposure to Diethylstilbestrol (DES), by Edward J. Saunders (2006), published in the journal Psychiatric Services
  
  
• Long-term Psychiatric and Behavioural Consequences of Prenatal Exposure to Psychoactive Drugs (2002), by Helene Verdoux, published in the journal Therapie (abstract only)
  
  
• Does Prenatal Exposure to Diethylstilbestrol (DES) have Psychiatric Consequences? (2000), by Helene Verdoux, published in the journal Annales Medico-Psychologiques, Vol 158 (2), p. 105-117 (Abstract only)
  
  
• Psychopathology and Social Functioning in Men Prenatally Exposed to Diethylstilbestrol (DES) (1993), by Richard C. Pillard, et. al, published in the journal Psychosomatic Medicine (abstract only)
  
  
• Gender-related Behavior Development in Females Exposed to Diethylstilbestrol (DES) in Utero: An Attempted Replication (1991), by Jennifer D. Lish, et. al, published in the Journal of the American Academy of Child & Adolescent Psychiatry (abstract only)
  
  1977-1990
  
  
• The Psychological Impact of Prenatal DES Exposure in Women: A Comparison of Short-term and Long-term Effects (1988), by M. Cloitre, et. al, published in the Journal of Psychosomatic Obstetrics and Gynecology (full-text)
  
  
• Physical and Psychological Problems Associated with Exposure to Diethylstilbestrol (DES) (1988), by E J Saunders, published in the journal Psychiatric Services (abstract only)
  
  
• BRIEF COMMUNICATION: Psychosis and Prenatal Exposure to Diethylstilbestrol (1987), by David L. Katz, et. al, published in the Journal of Nervous and Mental Disease (abstract only)
  
  
• Depression and Diethylstilbestrol Exposure in Women (1987), by M. Fried-Cassorla, et. al, published in The Journal of Reproductive Medicine (abstract)
  
  
• Psychopathology in Prenatally DES-Exposed Females: Current and Lifetime Adjustment (1987), by A A Ehrhardt, et. al, published in the journal Psychosomatic Medicine
  
  
• A Report of One Family with Four Autistic Siblings and Four Families with Three Autistic Siblings (1987), by Edward R. Ritvo, et. al, published in the Journal of the American Academy of Child & Adolescent Psychiatry
  
  
• Long-term Mental Health Effects of Prenatal DES Exposure (1986), by Anke A. Ehrhardt, published in the National Institutes of Health Research Digest (abstract only)
  
  
• Long-term Distress Subsequent to Pregnancy Drug Administration: Women with in utero Diethylstilbestrol (DES) Exposed Daughters (1985), by Elane Gutterman, et. al, published in the Journal of Psychosomatic Obstetrics & Gynecology (abstract only)
  
  
• Observations on the Psychological Impact of Diethylstilbestrol Exposure and Suggestions on Management (1980), by L. Burke, et. al, published in The Journal of Reproductive Medicine (abstract only)
  
  
• Psychological Effects of Diethylstilbestrol Exposure (1977), by RW Schwartz & NB Stewart, published in the Journal of the American Medical Association (JAMA) (abstract only)
  

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